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Unlike synthetic opioids, kratom doesn’t activate the same cellular “brakes” (called beta-arrestins) that cause tolerance build-up. That means users are less likely to need higher and higher doses.
In fact, taking too much kratom usually results in nausea and "fullness"—not a stronger high. That “diminishing returns” effect actually discourages overuse.
Key Takeaway
When taken from a reputable source (like ETHA!!) and taken responsibly, kratom is not considered chemically addictive like opioids. It offers potential benefits like natural discomfort relief , energy boost , and stress reduction—without the dangerous cycle of craving and dependence.
Christopher R. McCurdy, Ph.D., FAAPS, is a broadly trained medicinal chemist, behavioral pharmacologist and pharmacist whose research focuses on the design, synthesis and development of drugs to treat pain and drug abuse.
For over 20 years, much of his research has focused on opioid, Neuropeptide FF and sigma receptor ligand/probe design, synthesis, pharmacological evaluation and development. He has been successful in discovering unique and selective tools for sigma receptors, NPFF receptors and opioid receptors. He is an internationally recognized expert on Kratom (Mitragyna speciosa), that is under investigation for opioid withdrawal syndrome.
